Browsing by Subject "Drug products"

Now showing items 1-5 of 5

    • Article  

      De novo drug design using multiobjective evolutionary graphs 

      Nicolaou, Christos A.; Apostolakis, Joannis; Pattichis, Constantinos S. (2009)
      Drug discovery and development is a complex, lengthy process, and failure of a candidate molecule can occur as a result of a combination of reasons, such as poor pharmacokinetics, lack of efficacy, or toxicity. Successful ...
    • Article  

      Spin Crossover in Nitrito-Myoglobin as Revealed by Resonance Raman Spectroscopy 

      Lambrou, Alexandra; Ioannou, Androulla; Pinakoulaki, Eftychia (2016)
      The myoglobin (Mb) heme Fe-O-N=O and heme Fe-O-N=O/2-nitrovinyl species have been characterized by resonance Raman spectroscopy. In the heme Fe-O-N=O species, the bound nitrite ligand is removed by solvent exchange, thus ...
    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, Triantafyllos; Economides, Eva Athena; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
    • Conference Object  

      A workflow system for virtual screening in cancer chemoprevention 

      Kannas, Christos C.; Achilleos, Kleo G.; Antoniou, Zinonas C.; Nicolaou, Christos A.; Pattichis, Constantinos S.; Kalvari, Ioanna; Kirmitzoglou, Ioannis K.; Promponas, Vasilis J. (2012)
      Computer-aided drug discovery techniques have been widely used in recent years to support the development of new pharmaceuticals. Virtual screening, the computational counterpart of experimental screening, attempts to ...